Direct chromosome-length haplotyping by single-cell sequencing

Haplotypes are fundamental to fully characterize the diploid genome of an individual, yet methods to directly chart the unique genetic makeup of each parental chromosome are lacking. Here we introduce single-cell DNA template strand sequencing (Strand-seq) as a novel approach to phasing diploid geno...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Porubský, David, Sanders, Ashley D., van Wietmarschen, Niek, Falconer, Ester, Hills, Mark, Spierings, Diana C.J., Bevova, Marianna R., Guryev, Victor, Lansdorp, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088598/
https://ncbi.nlm.nih.gov/pubmed/27646535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.209841.116
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