Conditional knockout of Tsc1 in RORγt-expressing cells induces brain damage and early death in mice

BACKGROUND: Tuberous sclerosis complex 1 (Tsc1) is known to regulate the development and function of various cell types, and RORγt is a critical transcription factor in the immune system. However, whether Tsc1 participates in regulating RORγt-expressing cells remains unknown. METHODS: We generated a...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Deng, Yafei, Yang, Qinglan, Yang, Yao, Li, Yana, Peng, Hongyan, Wu, Shuting, Zhang, Shuju, Yao, Baige, Li, Shuhui, Gao, Yuan, Li, Xiaohui, Li, Liping, Deng, Youcai
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101034/
https://ncbi.nlm.nih.gov/pubmed/33957945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02153-8
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