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A bifunctional iminophosphorane squaramide catalyzed enantioselective synthesis of hydroquinazolines via intramolecular aza-Michael reaction to α,β-unsaturated esters

An efficient synthesis of enantioenriched hydroquinazoline cores via a novel bifunctional iminophosphorane squaramide catalyzed intramolecular aza-Michael reaction of urea-linked α,β-unsaturated esters is described. The methodology exhibits a high degree of functional group tolerance around the form...

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Publicat a:Chem Sci
Autors principals: Su, Guanglong, Thomson, Connor J., Yamazaki, Ken, Rozsar, Daniel, Christensen, Kirsten E., Hamlin, Trevor A., Dixon, Darren J.
Format: Artigo
Idioma:Inglês
Publicat: The Royal Society of Chemistry 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8098679/
https://ncbi.nlm.nih.gov/pubmed/33996002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc00856k
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