Enantioselective Desymmetrization of Prochiral Cyclohexanones by Organocatalytic Intramolecular Michael Additions to α,β-Unsaturated Esters**

A new catalytic asymmetric desymmetrization reaction for the synthesis of enantioenriched derivatives of 2-azabicyclo[3.3.1]nonane, a key motif common to many alkaloids, has been developed. Employing a cyclohexanediamine-derived primary amine organocatalyst, a range of prochiral cyclohexanone deriva...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Gammack Yamagata, Adam D, Datta, Swarup, Jackson, Kelvin E, Stegbauer, Linus, Paton, Robert S, Dixon, Darren J
Médium: Artigo
Jazyk:Inglês
Vydáno: WILEY-VCH Verlag 2015
Témata:
Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678487/
https://ncbi.nlm.nih.gov/pubmed/25727215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201411924
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