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Enantioselective bifunctional iminophosphorane catalyzed sulfa-Michael addition of alkyl thiols to unactivated β-substituted-α,β-unsaturated esters

The highly enantioselective sulfa-Michael addition of alkyl thiols to unactivated β-substituted-α,β-unsaturated esters catalyzed by a bifunctional iminophosphorane (BIMP) organocatalyst is described. The low acidity of the alkyl thiol pro-nucleophiles is overcome by the high Brønsted basicity of the...

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發表在:Chem Sci
Main Authors: Yang, Jinchao, Farley, Alistair J. M., Dixon, Darren J.
格式: Artigo
語言:Inglês
出版: Royal Society of Chemistry 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358540/
https://ncbi.nlm.nih.gov/pubmed/28451207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc02878k
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