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Bifunctional iminophosphorane catalysed enantioselective sulfa-Michael addition of alkyl thiols to alkenyl benzimidazoles

The first enantioselective sulfa-Michael addition of alkyl thiols to alkenyl benzimidazoles, enabled by a bifunctional iminophosphorane (BIMP) organocatalyst, is described. The iminophosphorane moiety of the catalyst provides the required basicity to deprotonate the thiol nucleophile while the chira...

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Publicado en:Chem Sci
Autores principales: Formica, Michele, Sorin, Geoffroy, Farley, Alistair J. M., Díaz, Jesús, Paton, Robert S., Dixon, Darren J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Royal Society of Chemistry 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124915/
https://ncbi.nlm.nih.gov/pubmed/30210771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc01804a
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