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Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures
Defects in DNA single‐strand break repair (SSBR) are linked with neurological dysfunction but the underlying mechanisms remain poorly understood. Here, we show that hyperactivity of the DNA strand break sensor protein Parp1 in mice in which the central SSBR protein Xrcc1 is conditionally deleted (Xr...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | EMBO Rep |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
John Wiley and Sons Inc.
2021
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8097344/ https://ncbi.nlm.nih.gov/pubmed/33932076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202051851 |
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