Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin

A critical step of DNA single-strand break repair is the rapid recruitment of the scaffold protein XRCC1 that interacts with, stabilizes and stimulates multiple enzymatic components of the repair process. XRCC1 recruitment is promoted by PARP1, an enzyme that is activated following DNA damage and sy...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Hanzlikova, Hana, Gittens, William, Krejcikova, Katerina, Zeng, Zhihong, Caldecott, Keith W.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389470/
https://ncbi.nlm.nih.gov/pubmed/27965414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1246
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