XRCC1 prevents toxic PARP1 trapping during DNA base excision repair

Mammalian DNA base excision repair (BER) is accelerated by poly(ADP-ribose) polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect single-strand break intermediates, but the critical role of XRCC1 during BER is unknown. Here, we show that protein complexes containing DNA p...

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Publicado no:Mol Cell
Principais autores: Demin, Annie A., Hirota, Kouji, Tsuda, Masataka, Adamowicz, Marek, Hailstone, Richard, Brazina, Jan, Gittens, William, Kalasova, Ilona, Shao, Zhengping, Zha, Shan, Sasanuma, Hiroyuki, Hanzlikova, Hana, Takeda, Shunichi, Caldecott, Keith W.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294329/
https://ncbi.nlm.nih.gov/pubmed/34102106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.05.009
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