Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures

Defects in DNA single‐strand break repair (SSBR) are linked with neurological dysfunction but the underlying mechanisms remain poorly understood. Here, we show that hyperactivity of the DNA strand break sensor protein Parp1 in mice in which the central SSBR protein Xrcc1 is conditionally deleted (Xr...

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Gepubliceerd in:EMBO Rep
Hoofdauteurs: Komulainen, Emilia, Badman, Jack, Rey, Stephanie, Rulten, Stuart, Ju, Limei, Fennell, Kate, Kalasova, Ilona, Ilievova, Kristyna, McKinnon, Peter J, Hanzlikova, Hana, Staras, Kevin, Caldecott, Keith W
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2021
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097344/
https://ncbi.nlm.nih.gov/pubmed/33932076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202051851
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