A High‐Affinity Calmodulin‐Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells

The molecular mechanisms and forces involved in the translocation of bacterial toxins into host cells are still a matter of intense research. The adenylate cyclase (CyaA) toxin from Bordetella pertussis displays a unique intoxication pathway in which its catalytic domain is directly translocated acr...

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Publicat a:Adv Sci (Weinh)
Autors principals: Voegele, Alexis, Sadi, Mirko, O'Brien, Darragh Patrick, Gehan, Pauline, Raoux‐Barbot, Dorothée, Davi, Maryline, Hoos, Sylviane, Brûlé, Sébastien, Raynal, Bertrand, Weber, Patrick, Mechaly, Ariel, Haouz, Ahmed, Rodriguez, Nicolas, Vachette, Patrice, Durand, Dominique, Brier, Sébastien, Ladant, Daniel, Chenal, Alexandre
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
Matèries:
Full Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097335/
https://ncbi.nlm.nih.gov/pubmed/33977052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202003630
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