A High‐Affinity Calmodulin‐Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells

The molecular mechanisms and forces involved in the translocation of bacterial toxins into host cells are still a matter of intense research. The adenylate cyclase (CyaA) toxin from Bordetella pertussis displays a unique intoxication pathway in which its catalytic domain is directly translocated acr...

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Udgivet i:Adv Sci (Weinh)
Main Authors: Voegele, Alexis, Sadi, Mirko, O'Brien, Darragh Patrick, Gehan, Pauline, Raoux‐Barbot, Dorothée, Davi, Maryline, Hoos, Sylviane, Brûlé, Sébastien, Raynal, Bertrand, Weber, Patrick, Mechaly, Ariel, Haouz, Ahmed, Rodriguez, Nicolas, Vachette, Patrice, Durand, Dominique, Brier, Sébastien, Ladant, Daniel, Chenal, Alexandre
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097335/
https://ncbi.nlm.nih.gov/pubmed/33977052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202003630
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