Endothelial IGF‐1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity

Changes in composition of the intestinal microbiota are linked to the development of obesity and can lead to endothelial cell (EC) dysfunction. It is unknown whether EC can directly influence the microbiota. Insulin‐like growth factor‐1 (IGF‐1) and its receptor (IGF‐1R) are critical for coupling nut...

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Pubblicato in:EMBO Rep
Autori principali: Haywood, Natalie J, Luk, Cheukyau, Bridge, Katherine I, Drozd, Michael, Makava, Natallia, Skromna, Anna, Maccannell, Amanda, Ozber, Claire H, Warmke, Nele, Wilkinson, Chloe G, Watt, Nicole T, Koch‐Paszkowski, Joanna, Teh, Irvin, Boyle, Jordan H, Smart, Sean, Schneider, Jurgen E, Yuldasheva, Nadira Y, Roberts, Lee D, Beech, David J, Sukumar, Piruthivi, Wheatcroft, Stephen B, Cubbon, Richard M, Kearney, Mark T
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097321/
https://ncbi.nlm.nih.gov/pubmed/33934497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050767
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