Endothelial IGF‐1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity

Changes in composition of the intestinal microbiota are linked to the development of obesity and can lead to endothelial cell (EC) dysfunction. It is unknown whether EC can directly influence the microbiota. Insulin‐like growth factor‐1 (IGF‐1) and its receptor (IGF‐1R) are critical for coupling nut...

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Veröffentlicht in:EMBO Rep
Hauptverfasser: Haywood, Natalie J, Luk, Cheukyau, Bridge, Katherine I, Drozd, Michael, Makava, Natallia, Skromna, Anna, Maccannell, Amanda, Ozber, Claire H, Warmke, Nele, Wilkinson, Chloe G, Watt, Nicole T, Koch‐Paszkowski, Joanna, Teh, Irvin, Boyle, Jordan H, Smart, Sean, Schneider, Jurgen E, Yuldasheva, Nadira Y, Roberts, Lee D, Beech, David J, Sukumar, Piruthivi, Wheatcroft, Stephen B, Cubbon, Richard M, Kearney, Mark T
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097321/
https://ncbi.nlm.nih.gov/pubmed/33934497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050767
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