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A Physiologically Based Pharmacokinetic Analysis To Predict the Pharmacokinetics of Intravenous Isavuconazole in Patients with or without Hepatic Impairment

Isavuconazole (ISA) is an azole antifungal used in the treatment of invasive aspergillosis and mucormycosis. Patients with mild or moderate hepatic impairment have lower clearance (CL) than the healthy population. Currently, there are no data on ISA in patients with severe hepatic impairment (Child-...

詳細記述

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書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Huang, Huiping, Xie, Helin, Chaphekar, Nupur, Xu, Ruichao, Venkataramanan, Raman, Wu, Xuemei
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092901/
https://ncbi.nlm.nih.gov/pubmed/33619060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02032-20
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