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A physiologically based pharmacokinetic modelling approach to predict buprenorphine pharmacokinetics following intravenous and sublingual administration

AIMS: Opioid dependence is associated with high morbidity and mortality. Buprenorphine (BUP) is approved by the Food and Drug Administration to treat opioid dependence. There is a lack of clear consensus on the appropriate dosing of BUP due to interpatient physiological differences in absorption/dis...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Kalluri, Hari V., Zhang, Hongfei, Caritis, Steve N., Venkataramanan, Raman
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651326/
https://ncbi.nlm.nih.gov/pubmed/28688108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13368
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