A physiologically based pharmacokinetic modelling approach to predict buprenorphine pharmacokinetics following intravenous and sublingual administration

AIMS: Opioid dependence is associated with high morbidity and mortality. Buprenorphine (BUP) is approved by the Food and Drug Administration to treat opioid dependence. There is a lack of clear consensus on the appropriate dosing of BUP due to interpatient physiological differences in absorption/dis...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Clin Pharmacol
Prif Awduron: Kalluri, Hari V., Zhang, Hongfei, Caritis, Steve N., Venkataramanan, Raman
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2017
Pynciau:
Pharmacokinetics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651326/
https://ncbi.nlm.nih.gov/pubmed/28688108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13368
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