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A Physiologically Based Pharmacokinetic Analysis To Predict the Pharmacokinetics of Intravenous Isavuconazole in Patients with or without Hepatic Impairment

Isavuconazole (ISA) is an azole antifungal used in the treatment of invasive aspergillosis and mucormycosis. Patients with mild or moderate hepatic impairment have lower clearance (CL) than the healthy population. Currently, there are no data on ISA in patients with severe hepatic impairment (Child-...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Antimicrob Agents Chemother
Main Authors: Huang, Huiping, Xie, Helin, Chaphekar, Nupur, Xu, Ruichao, Venkataramanan, Raman, Wu, Xuemei
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2021
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092901/
https://ncbi.nlm.nih.gov/pubmed/33619060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02032-20
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