Stabilizing the HIV-1 Envelope Glycoprotein State 2A Conformation

The HIV-1 envelope glycoprotein (Env) trimer [(gp120/gp41)(3)] is a metastable complex expressed at the surface of viral particles and infected cells that samples different conformations. Before engaging CD4, Env adopts an antibody-resistant “closed” conformation (State 1). CD4 binding triggers an i...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Vézina, Dani, Gong, Shang Yu, Tolbert, William D., Ding, Shilei, Nguyen, Dung, Richard, Jonathan, Gendron-Lepage, Gabrielle, Melillo, Bruno, Smith, Amos B., Pazgier, Marzena, Finzi, Andrés
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2021
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092833/
https://ncbi.nlm.nih.gov/pubmed/33298541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01620-20
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