Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner

Human immunodeficiency virus type 1 (HIV-1) capsid binds host proteins during infection, including cleavage and polyadenylation specificity factor 6 (CPSF6) and cyclophilin A (CypA). We observe that HIV-1 infection induces higher-order CPSF6 formation, and capsid-CPSF6 complexes cotraffic on microtu...

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Bibliographic Details
Published in:mBio
Main Authors: Zhong, Zhou, Ning, Jiying, Boggs, Emerson A., Jang, Sooin, Wallace, Callen, Telmer, Cheryl, Bruchez, Marcel P., Ahn, Jinwoo, Engelman, Alan N., Zhang, Peijun, Watkins, Simon C., Ambrose, Zandrea
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092277/
https://ncbi.nlm.nih.gov/pubmed/33758083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03142-20
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