Intrinsic curvature of HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A

The mature retrovirus capsid consists of a variably curved lattice of capsid protein (CA) hexamers and pentamers. High-resolution structures of the curved assembly, or in complex with host factors, have not been available. By devising new cryoEM methodologies for exceedingly flexible and pleomorphic...

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發表在:Nat Struct Mol Biol
Main Authors: Ni, Tao, Gerard, Samuel, Zhao, Gongpu, Dent, Kyle, Ning, Jiying, Zhou, Jing, Shi, Jiong, Anderson-Daniels, Jordan, Li, Wen, Jang, Sooin, Engelman, Alan N., Aiken, Christopher, Zhang, Peijun
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064030/
https://ncbi.nlm.nih.gov/pubmed/32747784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0467-8
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