Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site

The host cell factor cyclophilin A (CypA) interacts directly with the HIV-1 capsid and regulates viral infectivity. Although the crystal structure of CypA in complex with the N-terminal domain of the HIV-1 capsid protein (CA) has been known for nearly two decades, how CypA interacts with the viral c...

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Publicado no:Nat Commun
Main Authors: Liu, Chuang, Perilla, Juan R., Ning, Jiying, Lu, Manman, Hou, Guangjin, Ramalho, Ruben, Himes, Benjamin A., Zhao, Gongpu, Bedwell, Gregory J., Byeon, In-Ja, Ahn, Jinwoo, Gronenborn, Angela M., Prevelige, Peter E., Rousso, Itay, Aiken, Christopher, Polenova, Tatyana, Schulten, Klaus, Zhang, Peijun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785225/
https://ncbi.nlm.nih.gov/pubmed/26940118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10714
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