Capsid-CPSF6 interaction licenses nuclear HIV-1 trafficking to sites of viral DNA integration

HIV-1 integration into the host genome favors actively transcribed genes. Prior work indicated that the nuclear periphery provides the architectural basis for integration site selection, with viral capsid-binding host cofactor CPSF6 and viral integrase-binding cofactor LEDGF/p75 contributing to sele...

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Publicat a:Cell Host Microbe
Autors principals: Achuthan, Vasudevan, Perreira, Jill M., Sowd, Gregory A., Puray-Chavez, Maritza, McDougall, William M., Paulucci-Holthauzen, Adriana, Wu, Xiaolin, Fadel, Hind J., Poeschla, Eric M., Multani, Asha S., Hughes, Stephen H., Sarafianos, Stefan G., Brass, Abraham L., Engelman, Alan N.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368089/
https://ncbi.nlm.nih.gov/pubmed/30173955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.08.002
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