CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration

Lentiviral DNA integration favors transcriptionally active chromatin. We previously showed that the interaction of human immunodeficiency virus type 1 (HIV-1) capsid with cleavage and polyadenylation specificity factor 6 (CPSF6) localizes viral preintegration complexes (PICs) to nuclear speckles for...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Li, Wen, Singh, Parmit K., Sowd, Gregory A., Bedwell, Gregory J., Jang, Sooin, Achuthan, Vasudevan, Oleru, Amarachi V., Wong, Doris, Fadel, Hind J., Lee, KyeongEun, KewalRamani, Vineet N., Poeschla, Eric M., Herschhorn, Alon, Engelman, Alan N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527728/
https://ncbi.nlm.nih.gov/pubmed/32994325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02254-20
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