Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

Cleavage factor I mammalian (CFIm) complex, composed of cleavage and polyadenylation specificity factor 5 (CPSF5) and serine/arginine-like protein CPSF6, regulates alternative polyadenylation (APA). Loss of CFIm function results in proximal polyadenylation site usage, shortening mRNA 3′ untranslated...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Jang, Sooin, Cook, Nicola J, Pye, Valerie E, Bedwell, Gregory J, Dudek, Amanda M, Singh, Parmit K, Cherepanov, Peter, Engelman, Alan N
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511849/
https://ncbi.nlm.nih.gov/pubmed/30916345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz206
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