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NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation
Tumor necrosis factor receptor 1 (TNFR1) activates NF-κB–dependent pro-inflammatory gene expression, but also induces cell death by triggering apoptosis and necroptosis. Inhibition of inhibitor of NF-κB kinase (IKK)/NF-κB signaling in keratinocytes paradoxically unleashed spontaneous TNFR1-mediated...
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| Veröffentlicht in: | Life Sci Alliance |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Life Science Alliance LLC
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8091601/ https://ncbi.nlm.nih.gov/pubmed/33858959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000956 |
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