Differential Activity and Utilization of Glucocorticoid Receptor Binding Sites Yields Transcriptional Heterogeneity

Synthetic glucocorticoids such as Dexamethasone (Dex) are widely prescribed drugs used to treat a variety of human diseases including auto-immune disorders, asthma, cancer, and COVID-19. The transcriptional response to glucocorticoids is elicited by the Glucocorticoid Receptor (GR), which enters the...

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Bibliografske podrobnosti
izdano v:J Endocr Soc
Main Authors: Hoffman, Jackson Andrew, Trotter, Kevin W, Day, Christopher R, Ward, James M, Rodriguez, Joseph, Archer, Trevor K
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2021
Teme:
Genetics and Development (including Gene Regulation)
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090539/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.1021
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