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Hepatic GH Receptor Signaling Directly Suppresses Hepatic Steatosis and De Novo Lipogenesis, Independent of Changes in Plasma IGF1 and Insulin

A reduction in GH, as well as IGF1, is associated with non-alcoholic fatty liver disease (NAFLD). However, the relative contribution of changes in circulating GH and IGF1, to hepatic triglyceride accumulation (steatosis), remains to be clearly defined. To study the direct actions of GH on hepatocyte...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Vazquez Borrego, Maria del Carmen, Moreno, Mercedes del Rio, Sarmento-Cabral, Andre, Mahmood, Mariyah, Subbaiah, Papasani V, Yakar, Shoshana, Cordoba-Chacon, Jose, Puchowicz, Michelle, Kineman, Rhonda D
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8089597/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.095
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