SUN-LB52 The Protective Effects of Hepatocyte GH Receptor (GHR) Signaling Against Steatosis and Liver Injury Is Sexually Dimorphic and Autonomous of IGF1

GH dysregulation contributes to the development of non-alcoholic fatty liver disease (NAFLD), however debate remains as to the relative contribution of the direct vs indirect effects of GH, via IGF1. Mouse models with congenital, liver-specific knockout of the GHR, JAK2 or STAT5, as adults exhibit s...

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Vydáno v:J Endocr Soc
Hlavní autoři: Sarmento-Cabral, Andre, del Rio-Moreno, Mercedes, Vazquez-Borrego, Mari C, Mahmood, Mariyah, Gutierrez-Casado, Elena, Guzman, Grace, Subbaiah, Papasani V, Cordoba-Chacon, Jose, Yakar, Shoshana, Kineman, Rhonda D
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Neuroendocrinology and Pituitary
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208591/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.2287
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