High-resolution, ultra-sensitive and quantitative DNA double-strand break labeling in eukaryotic cells using i-BLESS

DNA double-strand breaks (DSBs) are implicated in various physiological processes, such as class-switch recombination or crossing-over during meiosis, but also present a threat to genome stability. Extensive evidence shows that DSBs are a primary source of chromosome translocations or deletions, mak...

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Udgivet i:Nat Protoc
Main Authors: Biernacka, Anna, Skrzypczak, Magdalena, Zhu, Yingjie, Pasero, Philippe, Rowicka, Maga, Ginalski, Krzysztof
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8088906/
https://ncbi.nlm.nih.gov/pubmed/33349705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41596-020-00448-3
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