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Nucleotide-resolution DNA double-strand breaks mapping by next-generation sequencing
We present a genome-wide method to map DNA double-strand breaks (DSBs) at nucleotide resolution by direct in situ breaks labeling, enrichment on streptavidin, and next-generation sequencing (BLESS). We comprehensively validated and tested BLESS using different human and mouse cells, DSBs-inducing ag...
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| Main Authors: | , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3651036/ https://ncbi.nlm.nih.gov/pubmed/23503052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2408 |
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