Genome wide mapping of long range contacts unveils DNA Double Strand Breaks clustering at damaged active genes

The ability of DNA Double Strand Breaks (DSBs) to cluster in mammalian cells has been subjected to intense debate over the past few years. Here we used a high throughput chromosome conformation capture assay (Capture Hi-C) to investigate clustering of DSBs induced at defined loci in the human genome...

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Veröffentlicht in:Nat Struct Mol Biol
Hauptverfasser: Aymard, François, Aguirrebengoa, Marion, Guillou, Emmanuelle, Javierre, Biola M, Bugler, Beatrix, Arnould, Coline, Rocher, Vincent, Iacovoni, Jason S, Biernacka, Anna, Skrzypczak, Magdalena, Ginalski, Krzysztof, Rowicka, Maga, Fraser, Peter, Legube, Gaëlle
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385132/
https://ncbi.nlm.nih.gov/pubmed/28263325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3387
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