Beryllium-specific CD4(+) T cells induced by chemokine neoantigens perpetuate inflammation

Discovering dominant epitopes for T cells, particularly CD4(+) T cells, in human immune-mediated diseases remains a significant challenge. Here, we used bronchoalveolar lavage (BAL) cells from HLA-DP2–expressing patients with chronic beryllium disease (CBD), a debilitating granulomatous lung disorde...

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Udgivet i:J Clin Invest
Main Authors: Falta, Michael T., Crawford, Jeremy C., Tinega, Alex N., Landry, Laurie G., Crawford, Frances, Mack, Douglas G., Martin, Allison K., Atif, Shaikh M., Li, Li, Santos, Radleigh G., Nakayama, Maki, Kappler, John W., Maier, Lisa A., Thomas, Paul G., Pinilla, Clemencia, Fontenot, Andrew P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087207/
https://ncbi.nlm.nih.gov/pubmed/33630763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI144864
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