Beryllium-specific CD4(+) T cells induced by chemokine neoantigens perpetuate inflammation

Discovering dominant epitopes for T cells, particularly CD4(+) T cells, in human immune-mediated diseases remains a significant challenge. Here, we used bronchoalveolar lavage (BAL) cells from HLA-DP2–expressing patients with chronic beryllium disease (CBD), a debilitating granulomatous lung disorde...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Falta, Michael T., Crawford, Jeremy C., Tinega, Alex N., Landry, Laurie G., Crawford, Frances, Mack, Douglas G., Martin, Allison K., Atif, Shaikh M., Li, Li, Santos, Radleigh G., Nakayama, Maki, Kappler, John W., Maier, Lisa A., Thomas, Paul G., Pinilla, Clemencia, Fontenot, Andrew P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087207/
https://ncbi.nlm.nih.gov/pubmed/33630763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI144864
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