Beryllium-specific CD4(+) T cells induced by chemokine neoantigens perpetuate inflammation

Discovering dominant epitopes for T cells, particularly CD4(+) T cells, in human immune-mediated diseases remains a significant challenge. Here, we used bronchoalveolar lavage (BAL) cells from HLA-DP2–expressing patients with chronic beryllium disease (CBD), a debilitating granulomatous lung disorde...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Falta, Michael T., Crawford, Jeremy C., Tinega, Alex N., Landry, Laurie G., Crawford, Frances, Mack, Douglas G., Martin, Allison K., Atif, Shaikh M., Li, Li, Santos, Radleigh G., Nakayama, Maki, Kappler, John W., Maier, Lisa A., Thomas, Paul G., Pinilla, Clemencia, Fontenot, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087207/
https://ncbi.nlm.nih.gov/pubmed/33630763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI144864
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