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DNA Double-Strand Breaks: A Double-Edged Sword for Trypanosomatids

For nearly all eukaryotic cells, stochastic DNA double-strand breaks (DSBs) are one of the most deleterious types of DNA lesions. DSB processing and repair can cause sequence deletions, loss of heterozygosity, and chromosome rearrangements resulting in cell death or carcinogenesis. However, trypanos...

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Détails bibliographiques
Publié dans:Front Cell Dev Biol
Auteur principal: da Silva, Marcelo Santos
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8085331/
https://ncbi.nlm.nih.gov/pubmed/33937271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.669041
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