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Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase
O-GlcNAc is an essential and dynamic post-translational modification presented on thousands of nucleocytoplasmic proteins. Interrogating the role of O-GlcNAc on a single target protein is crucial yet challenging to perform in cells. Herein, we developed a nanobody-fused split O-GlcNAcase (OGA) as an...
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| Veröffentlicht in: | Nat Chem Biol |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8085020/ https://ncbi.nlm.nih.gov/pubmed/33686291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-021-00757-y |
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