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Structural and functional insight into human O-GlcNAcase
O-GlcNAc hydrolase, OGA, removes O-linked N-acetylglucosamine (O-GlcNAc) from myriad nucleocytoplasmic proteins. Through co-expression and assembly of OGA fragments we determined the 3-D structure of human OGA, revealing an unusual helix exchanged dimer that lays a structural foundation for an impro...
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| Izdano u: | Nat Chem Biol |
|---|---|
| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5438047/ https://ncbi.nlm.nih.gov/pubmed/28346405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2358 |
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