Structural and functional insight into human O-GlcNAcase

O-GlcNAc hydrolase, OGA, removes O-linked N-acetylglucosamine (O-GlcNAc) from myriad nucleocytoplasmic proteins. Through co-expression and assembly of OGA fragments we determined the 3-D structure of human OGA, revealing an unusual helix exchanged dimer that lays a structural foundation for an impro...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Chem Biol
Main Authors: Roth, Christian, Chan, Sherry, Offen, Wendy A, Hemsworth, Glyn R, Willems, Lianne I, King, Dustin T, Varghese, Vimal, Britton, Robert, Vocadlo, David J, Davies, Gideon J
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438047/
https://ncbi.nlm.nih.gov/pubmed/28346405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2358
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker