Structural and functional insight into human O-GlcNAcase

O-GlcNAc hydrolase, OGA, removes O-linked N-acetylglucosamine (O-GlcNAc) from myriad nucleocytoplasmic proteins. Through co-expression and assembly of OGA fragments we determined the 3-D structure of human OGA, revealing an unusual helix exchanged dimer that lays a structural foundation for an impro...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Chem Biol
Egile Nagusiak: Roth, Christian, Chan, Sherry, Offen, Wendy A, Hemsworth, Glyn R, Willems, Lianne I, King, Dustin T, Varghese, Vimal, Britton, Robert, Vocadlo, David J, Davies, Gideon J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438047/
https://ncbi.nlm.nih.gov/pubmed/28346405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2358
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