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Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation
Abnormal hyperphosphorylation of microtubule-associated protein tau plays a crucial role in neurodegeneration in Alzheimer's disease (AD). The aggregation of hyperphosphorylated tau into neurofibrillary tangles is also a hallmark brain lesion of AD. Tau phosphorylation is regulated by tau kinas...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2012
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3334936/ https://ncbi.nlm.nih.gov/pubmed/22536363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035277 |
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