Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation

Abnormal hyperphosphorylation of microtubule-associated protein tau plays a crucial role in neurodegeneration in Alzheimer's disease (AD). The aggregation of hyperphosphorylated tau into neurofibrillary tangles is also a hallmark brain lesion of AD. Tau phosphorylation is regulated by tau kinas...

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Main Authors: Yu, Yang, Zhang, Lan, Li, Xiaojing, Run, Xiaoqin, Liang, Zhihou, Li, Yi, Liu, Ying, Lee, Moon H., Grundke-Iqbal, Inge, Iqbal, Khalid, Vocadlo, David J., Liu, Fei, Gong, Cheng-Xin
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334936/
https://ncbi.nlm.nih.gov/pubmed/22536363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035277
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