Inducible knockout of Clec16a in mice results in sensory neurodegeneration

CLEC16A has been shown to play a role in autophagy/mitophagy processes. Additionally, genetic variants in CLEC16A have been implicated in multiple autoimmune diseases. We generated an inducible whole-body knockout, Clec16a(ΔUBC) mice, to investigate the loss of function of CLEC16A. The mice exhibite...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Hain, Heather S., Pandey, Rahul, Bakay, Marina, Strenkowski, Bryan P., Harrington, Danielle, Romer, Micah, Motley, William W., Li, Jian, Lancaster, Eunjoo, Roth, Lindsay, Grinspan, Judith B., Scherer, Steven S., Hakonarson, Hakon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8084945/
https://ncbi.nlm.nih.gov/pubmed/33927318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88895-0
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky