The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice

CLEC16A locus polymorphisms have been associated with several autoimmune diseases. We overexpressed CLEC16A in YTS natural killer (NK) cells and observed reduced NK cell cytotoxicity and IFN-γ release, delayed dendritic cell (DC) maturation, decreased conjugate formation, cell-surface receptor downr...

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Bibliografski detalji
Izdano u:Front Immunol
Glavni autori: Pandey, Rahul, Bakay, Marina, Hain, Heather S., Strenkowski, Bryan, Yermakova, Anastasiya, Kushner, Jake A., Orange, Jordan S., Hakonarson, Hakon
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Immunology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367972/
https://ncbi.nlm.nih.gov/pubmed/30774629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00068
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