Inducible knockout of Clec16a in mice results in sensory neurodegeneration

CLEC16A has been shown to play a role in autophagy/mitophagy processes. Additionally, genetic variants in CLEC16A have been implicated in multiple autoimmune diseases. We generated an inducible whole-body knockout, Clec16a(ΔUBC) mice, to investigate the loss of function of CLEC16A. The mice exhibite...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hain, Heather S., Pandey, Rahul, Bakay, Marina, Strenkowski, Bryan P., Harrington, Danielle, Romer, Micah, Motley, William W., Li, Jian, Lancaster, Eunjoo, Roth, Lindsay, Grinspan, Judith B., Scherer, Steven S., Hakonarson, Hakon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8084945/
https://ncbi.nlm.nih.gov/pubmed/33927318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88895-0
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