The diabetes susceptibility gene Clec16a regulates mitophagy

Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an...

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Hoofdauteurs: Soleimanpour, Scott A., Gupta, Aditi, Bakay, Marina, Ferrari, Alana M., Groff, David N., Fadista, João, Spruce, Lynn A., Kushner, Jake A., Groop, Leif, Seeholzer, Steven H., Kaufman, Brett A., Hakonarson, Hakon, Stoffers, Doris A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184276/
https://ncbi.nlm.nih.gov/pubmed/24949970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.05.016
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