The diabetes susceptibility gene Clec16a regulates mitophagy

Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Soleimanpour, Scott A., Gupta, Aditi, Bakay, Marina, Ferrari, Alana M., Groff, David N., Fadista, João, Spruce, Lynn A., Kushner, Jake A., Groop, Leif, Seeholzer, Steven H., Kaufman, Brett A., Hakonarson, Hakon, Stoffers, Doris A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184276/
https://ncbi.nlm.nih.gov/pubmed/24949970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.05.016
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky