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The diabetes susceptibility gene Clec16a regulates mitophagy
Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an...
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| Autors principals: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4184276/ https://ncbi.nlm.nih.gov/pubmed/24949970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.05.016 |
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