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Calcineurin Signaling Regulates Human Islet β-Cell Survival

The calcium-regulated phosphatase calcineurin intersects with both calcium and cAMP-mediated signaling pathways in the pancreatic β-cell. Pharmacologic calcineurin inhibition, necessary to prevent rejection in the setting of organ transplantation, is associated with post-transplant β-cell failure. W...

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Detalhes bibliográficos
Main Authors: Soleimanpour, Scott A., Crutchlow, Michael F., Ferrari, Alana M., Raum, Jeffrey C., Groff, David N., Rankin, Matthew M., Liu, Chengyang, De León, Diva D., Naji, Ali, Kushner, Jake A., Stoffers, Doris A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000987/
https://ncbi.nlm.nih.gov/pubmed/20943662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.154955
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