Exendin-4 normalizes islet vascularity in intrauterine growth restricted rats: potential role of VEGF

Intrauterine growth restriction induced by uterine artery ligation in pregnant rats leads to low birth weight and early insulin secretory defects followed by the development of insulin resistance, decline in β-cell mass, and diabetes in adulthood. Neonatal administration of Exendin-4 (Ex-4) prevents...

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Main Authors: Ham, J. Nina, Crutchlow, Michael F., Desai, Biva M., Simmons, Rebecca A., Stoffers, Doris A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735861/
https://ncbi.nlm.nih.gov/pubmed/19287346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1203/PDR.0b013e3181a282a5
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