Neonatal Exendin-4 Reduces Growth, Fat Deposition and Glucose Tolerance during Treatment in the Intrauterine Growth-Restricted Lamb

BACKGROUND: IUGR increases the risk of type 2 diabetes mellitus (T2DM) in later life, due to reduced insulin sensitivity and impaired adaptation of insulin secretion. In IUGR rats, development of T2DM can be prevented by neonatal administration of the GLP-1 analogue exendin-4. We therefore investiga...

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Detalhes bibliográficos
Main Authors: Gatford, Kathryn L., Sulaiman, Siti A., Mohammad, Saidatul N. B., De Blasio, Miles J., Harland, M. Lyn, Simmons, Rebecca A., Owens, Julie A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570470/
https://ncbi.nlm.nih.gov/pubmed/23424667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056553
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