Neonatal Exendin-4 Reduces Growth, Fat Deposition and Glucose Tolerance during Treatment in the Intrauterine Growth-Restricted Lamb

BACKGROUND: IUGR increases the risk of type 2 diabetes mellitus (T2DM) in later life, due to reduced insulin sensitivity and impaired adaptation of insulin secretion. In IUGR rats, development of T2DM can be prevented by neonatal administration of the GLP-1 analogue exendin-4. We therefore investiga...

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Autors principals: Gatford, Kathryn L., Sulaiman, Siti A., Mohammad, Saidatul N. B., De Blasio, Miles J., Harland, M. Lyn, Simmons, Rebecca A., Owens, Julie A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570470/
https://ncbi.nlm.nih.gov/pubmed/23424667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056553
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