Fast and efficient purification of SARS-CoV-2 RNA dependent RNA polymerase complex expressed in Escherichia coli

To stop the COVID-19 pandemic due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which caused more than 2.5 million deaths to date, new antiviral molecules are urgently needed. The replication of SARS-CoV-2 requires the RNA-dependent RNA polymerase (RdRp), making RdRp an excell...

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Publicado en:PLoS One
Autores principales: Madru, Clément, Tekpinar, Ayten Dizkirici, Rosario, Sandrine, Czernecki, Dariusz, Brûlé, Sébastien, Sauguet, Ludovic, Delarue, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2021
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8084133/
https://ncbi.nlm.nih.gov/pubmed/33914787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0250610
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