Mass Balance Study of the Engineered Cationic Antimicrobial Peptide, WLBU2, Following a Single Intravenous Dose of 14C-WLBU2 in Mice

BACKGROUND: To address multidrug resistance, we developed engineered cationic antimicrobial peptides (eCAPs). Lead eCAP WLBU2 displays potent activity against drug-resistant bacteria and effectively treats lethal bacterial infections in mice, reducing bacterial loads to undetectable levels in divers...

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發表在:Curr Rev Clin Exp Pharmacol
Main Authors: Beumer, Jan H., Guo, Jianxia, Ray, Evan C., Scemama, Jonas, Parise, Robert A., Deslouches, Berthony, Steckbeck, Jonathan D., Montelaro, Ronald C., Eiseman, Julie L.
格式: Artigo
語言:Inglês
出版: 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8083974/
https://ncbi.nlm.nih.gov/pubmed/32778037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1574884715666200810094201
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