Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors

PURPOSE: Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is a key pathological event in proliferative retinal diseases such as proliferative vitreoretinopathy (PVR). This study aimed to explore a new method to reverse EMT in RPE cells to develop an improved therapy...

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Enregistré dans:
Détails bibliographiques
Publié dans:Invest Ophthalmol Vis Sci
Auteurs principaux: Chen, Yi, Wu, Binxin, He, Jian Feng, Chen, Jingyao, Kang, Zi Wei, Liu, Dandan, Luo, Junjie, Fang, Kexin, Leng, Xiaoxu, Tian, Haibin, Xu, Jingying, Jin, Caixia, Zhang, Jieping, Wang, Juan, Zhang, Jingfa, Ou, Qingjian, Lu, Lixia, Gao, Furong, Xu, Guo-Tong
Format: Artigo
Langue:Inglês
Publié: The Association for Research in Vision and Ophthalmology 2021
Sujets:
Retinal Cell Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8083104/
https://ncbi.nlm.nih.gov/pubmed/33861322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.62.4.21
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