Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors

PURPOSE: Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is a key pathological event in proliferative retinal diseases such as proliferative vitreoretinopathy (PVR). This study aimed to explore a new method to reverse EMT in RPE cells to develop an improved therapy...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Chen, Yi, Wu, Binxin, He, Jian Feng, Chen, Jingyao, Kang, Zi Wei, Liu, Dandan, Luo, Junjie, Fang, Kexin, Leng, Xiaoxu, Tian, Haibin, Xu, Jingying, Jin, Caixia, Zhang, Jieping, Wang, Juan, Zhang, Jingfa, Ou, Qingjian, Lu, Lixia, Gao, Furong, Xu, Guo-Tong
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2021
Assuntos:
Retinal Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8083104/
https://ncbi.nlm.nih.gov/pubmed/33861322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.62.4.21
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